Jose Francisco Torres received his first start of the season for Pachuca who fell at Monterrey while Jonathan Bornstein helped key a Tigres victory at Santos.
Monterrey 2 - 0 Pachuca
Jose Francisco Torres and Herculez Gomez each received starts against Monterrey but it was not enough to overtake the Apertura champions on Saturday evening at Estadio Tecnologico in Monterrey.
Both Torres and Gomez went the distance in the defeat with Torres picking up a yellow card in the 31st minute.
Monterrey scored the first of their two goals in the 26th minute when Neri Cardozo played in a cross from the left side to Aldo De Nigris that the Mexican international flicked on with a header past flat-footed Pachuca goalkeeper Miguel Calero.
Things grew increasingly worse for the Tuzos four minutes later when Leobardo López was sent off with a straight red card for a foul on Luis Perez leaving Pachuca a man down with still an hour left in the match.
The Rayados made them pay four minutes after the break when Humberto 'El Chupete' Suazo magnificently set up Cardozo for another strike.
Some poor defending by the Tuzos allowed Monterrey to strip possession and it was Suazo who drew in a crowd of defenders toward him.
The Chilean then lofted a cross to Cardozo who volleyed it home to double the margin and effectively seal the match.
Gomez and Torres will hope to do better next week when they host Edgar Castillo and Puebla.
Santos 0 - 2 Tigres
Jonathan Bornstein kickstarted a Tigres win with an assist as the Felinos downed the Apertura runners-up on Saturday night at Estadio TSM Corona in Torreon.
Bornstein started in the midfield and went the first 79 minutes before yielding his spot to Jesus Molina.
It took just the eighth minute before the US international left a mark on the match when he gathered in a ball down the left side and sent a perfect cross over to Hector Mancilla for the easy tap-in.
The guests then doubled the margin just a minute before halftime when Lucas Lobos looped in a ball that found an onrushing Juninho who headed it in.
The Tigres defense finished out the match with a strong second half as the Monterrey club continues to play well on the road in the Clausura.
Bornstein and company return home next week to take on Cruz Azul.
San Luis 3 - 2 Estudiantes
Daniel Antunez saw half an hour of action for Estudiantes who coughed up a two goal lead against San Luis on Saturday at Alfonso Lastras Ramírez.
Antunez came on in the 61st minute as a defender and replaced Rafael Medina.
Fellow American Sammy Ochoa did not see the field for the guests.
Estudiantes jumped out to a lead in the 21st with a goal from Elgabry Rangel in the 20th minute who slotted home from about 11 meters away.
They then seemingly took a large leap toward a win with another goal in the 54th minute as Rubens Sambueza fired in a left-footed shot that snuck inside the near post.
But then the Potosinos began their comeback and it started with Luis Omar Hernández heading in a corner kick in the 62nd minute.
San Luis then equalized in the 78th when Othoniel Arce set up Juan Manuel Cavallo who fired home to knot things up at two after Estudiantes goalkeeper Christian Martinez foolishly came off his line trying to secure the ball.
The gamewinner came two minutes from time when Wilmer Alexander Aguirre converted a penalty kick after being brought down in the area by Manuel Moran.
Moran was tugging on Aguirre's shirt outside of the area but that action carried into the box and the referee whistled the foul and pointed to the spot. It was also Moran's second yellow of the game.
The call enraged the visitors and shortly thereafter their tempers flared out of control and additional two players were sent off.
Estudiantes will try to regroup next weekend when they face Morelia.
Puebla 0 - 1 Pumas
Edgar Castillo and Puebla lost another heartbreaker, this time to red-hot Pumas on Sunday afternoon at Estadio Cuauhtémoc in Puebla.
Castillo started for the hosts and went the full 90 minutes. The on-loan player from America also picked up a yellow card in the 55th minute for a hard tackle on Javier Cortes.
The game's lone goal came in the 89th minute of play when Emilio Orrantia rifled in a shot that slipped to the left of Puebla goalkeeper Alexandro Alvarez.
It was a just goal for the visitors who were applying late pressure on castillo and the rest of the Puebla defense.
Next weekend Castillo and Puebla will pay a visit to Jose Francisco Toress and Herculez Gomez's Pachuca.
Isaac Acuna did not feature for Gallos Blancos who fell at America.