Sasha Kljestan and Anderlecht aim for a second straight Eerste Klasse win when they travel to Stade du Pays de Charleroi on Saturday to face Royal Charleroi SC.
Last Saturday's league opener versus AS Eupen saw Kljestan start the match on the bench but was soon called by head coach Areil Jacobs to replace injured midfielder Lucas Biglia.
The Argentine's shoulder injury opens the door for the former Chivas USA man to take a place in Jacobs' starting lineup against the Zebras.
While Kljestan's play in two Champions League victories over Welsh club The New Saints has been solid with a goal and an assist, last week's 4-1 win saw the American play a bit more tentative and hesitant, something he will hope to rectify on Saturday.
The three goal victory over Eupen placed Anderlecht at the top of the league standings but a test versus a rejuvenated Charleroi awaits the Purple & White this weekend.
The hosts are directed by Jacky Mathijssen who is affectionately known as "The Little Mourinho" in Belgian soccer circles for his propensity to play mind games via the media.
Unlike the renowned Portuguese boss, Mathijssen's success as a coach has been fairly muted as he begins his first season at Charleroi after leading fellow Eerste Klasse team Lokeren to a rather unspectacular 14th place.
Charleroi are coming off a disappointing 13th place finish in last year's campaign but a splitting of the points last week at Cercle Brugge offered a glimpse that this season the club could be on the rise.
Togolese striker Adekambi Olufade is out for the hosts while Anderlecht will be without the aforementioned Biglia plus Cheikhou Kouyate and Kanu.